Posolo Tuilagi, a teenage lock, will start for France for the first time on Sunday when Les Blues take on Italy in Lille during the Six Nations.
Paul Gabrillagues, who is left off of the matchday roster, is replaced by 19-year-old Tualigi, one of two changes.
Paul Boudehent comes in for the injured Gregory Alldritt with Charles Ollivon made captain in the forward’s absence.
Italy make six changes with Ross Vintcent and Riccardo Favretto set for their first Azzurri starts.