The Israeli military said it intercepted a ballistic missile fired by Houthi militants in Yemen targeting the southern city of Eilat.
It said the missile was intercepted before reaching Israeli territory.
Hours earlier, Israeli warplanes struck several targets in the militia-controlled port city of Hodeidah in Yemen. That strike was in response to an earlier Houthi strike that hit Tel Aviv on Friday.
Houthi spokesman Mohammed Abdulsalam said the strikes made its forces more determined to support Gaza.
Iran-aligned groups, including the Houthis, have fired rockets and missiles at Israel, saying they are doing so in support of Palestinians and the militant group Hamas that controls Gaza.
