All five killed were in the van, Stone County Coroner Wayne Flurry said. The lone surviving van passenger, a 23-year-old woman, was flown to a hospital, Flurry said. No one aboard the train was reported injured.
The crash occurred when a Canadian Pacific Kansas City freight train collided with a vehicle in a crossing, the railroad said in a statement. The location was near the town of Wiggins about 45 miles (72 kilometers) northwest of Biloxi.
The Stone County Sheriff’s Office was investigating the crash, the company said.

