Police searched a residence about two miles from the home of Nancy Guthrie, the missing mother of US news anchor Savannah Guthrie, on Friday night.
The search warrant was based on a lead investigators had received, but no arrests were made, the Pima County sheriff’s department said.
A person was also questioned at a traffic stop on Friday night, but was released, the department added.
It comes after local officials said investigators had found DNA at Guthrie’s address that did not belong to her or anyone close to her.
The 84-year-old disappeared in the middle of night from her home in Tucson, Arizona, two weeks ago. Authorities believe she was taken against her will.
The sheriff’s department confirmed on Saturday that law enforcement officers had executed a federal court-ordered search warrant based on a lead at the residence in connection with the Guthrie case.
The department did not provide further details about the lead or the residents of the house, saying only that no one was arrested.
More than a dozen law enforcement vehicles, both marked and unmarked, were seen in the area by BBC News, including Swat teams and forensics.
Armed police teams were seen coming in and out of the area, with a sheriff’s vehicle blocking the road.
Investigators have also found several gloves, with the closest discovered about two miles from Nancy Guthrie’s home.
The sheriff’s department said reports that a glove was found inside her home or on the property were inaccurate.
All collected evidence had been sent for laboratory analysis, they added.
On Thursday, the FBI released a physical description of the suspect, describing them as a male between 5ft 9in and 5ft 10in (175-177cm) with an average build.
It said investigators had been able to establish identifying details about the suspect after analysing footage from a doorbell camera outside Guthrie’s home
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